Summary of the blockade potency of bupropion on different pharmacological actions of nicotine after s.c. and i.t. administration in mice
| Pharmacological Effect or Test | AD50 |
|---|---|
| mg/kg | |
| Tail-flick after s.c. | 2.4 (2.0–3.6) |
| Tail-flick after i.t. | 9.0 (2.5–30)2-a |
| Hot-plate | 8.0 (5.9–10.9) |
| Hypomotility | 4.0 (3.5–6.3) |
| Seizures | 4.5 (4.2–5.3) |
| Hypothermia | 8.5 (4–18.3) |
AD50 values [±confidence limits (CL)] were calculated from the dose-response curves and expressed as milligrams per kilogram. Each dose group included six to eight animals.
↵2-a AD50 values (±CL) after i.t. administration are expressed as micrograms per animal.