NSAIDs do not interfere with the anti-HIV activity of adefovir
| NSAID | Adefovir IC50 |
|---|---|
| μM | |
| − | 3.5 ± 0.5 |
| Diflunisal3-a | 0.65 ± 0.05 |
| Ibuprofen | 1.5 ± 1 |
| Ketoprofen | 0.9 ± 0.3 |
| Naproxen | 1.8 ± 1.2 |
MT2 cells were infected with HIV-1(IIIb) and treated with various concentrations of adefovir in the absence or presence of 100 μM NSAIDs. After 5 days, an 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide assay was performed, and adefovir IC50 values were determined. The data represent mean ± S.D. from two independent experiments.
↵3-a Adefovir was tested in the presence of 30 μM diflunisal due to the cytotoxicity of diflunisal at 100 μM.