Table 7

The effect of the repeated p.o. administration of 0.1 and 0.3 mg/kg of SB-277011-A and haloperidol on the number of spontaneously active A9 and A10 DA neurons in anesthetized male Sprague-Dawley rats

Treatment	Dose (p.o.)	DA Cells/Track
Treatment	Dose (p.o.)	A9	A10
	mg/kg
Vehicle		0.82 ± 0.07^7-a	1.20 ± 0.10
SB-277011-A	0.1	0.91 ± 0.09	1.10 ± 0.10
SB-277011-A	0.3	0.80 ± 0.06	1.30 ± 0.17
Haloperidol	0.5	0.40 ± 0.07^7-b	0.48 ± 0.07^7-b

A total of 10 rats were examined for each treatment. Animals were given either vehicle (2% methylcellulose, 1 ml/kg), haloperidol, or SB-277011-A once a day for 21 consecutive days, and the experiments were conducted 2 h later.

↵7-a Each value represents the mean number of spontaneously active DA neurons detected per stereotaxic descent ± S.E.
↵7-b Significantly less than vehicle and all doses of SB-277011-A, P < .01, ANOVA and Student-Newman-Keul's test.