Table 1

The effect of i.v. administration of SB-277011-A on the basal firing rate and pattern of spontaneously active A9 DA neurons

ParameterDose of SB-277011-A (μg/kg)
0102040801603206401280
Spikes/burst1-a 2.8  ± 0.82.9  ± 0.52.4  ± 0.72.7  ± 0.62.8  ± 0.62.3  ± 0.42.7  ± 0.52.6  ± 0.62.8  ± 0.4
Interspike interval (ms)1-a 197  ± 17203  ± 20197  ± 17193  ± 16200  ± 17202  ± 18190  ± 16197  ± 17190  ± 14
Percentage of events as bursts1-b 6978107121110
Coefficient of variation1-a 33  ± 436  ± 536  ± 537  ± 437  ± 434  ± 238  ± 536  ± 439  ± 4

A total of nine neurons were examined at each dose. SB-277011-A was given i.v. in a cumulative fashion.

  • ↵1-a  Each value represents the mean ± S.E.

  • ↵1-b  Each value represents the mean.