The effect of the repeated administration of vehicle and SB-277011-A on spontaneously active burst-firing A9 and A10 DA neurons
| Parameter | Control | SB (1 mg/kg) | SB (3 mg/kg) | SB (10 mg/kg) | ||||
|---|---|---|---|---|---|---|---|---|
| A9 | A10 | A9 | A10 | A9 | A10 | A9 | A10 | |
| Spikes/burst | 3.8 ± 0.410-a | 4.1 ± 0.3 | 4.0 ± 0.4 | 3.8 ± 0.3 | 3.5 ± 0.3 | 2.8 ± 0.2 | 2.9 ± 0.210-b | 2.9 ± 0.1 |
| Interspike interval (ms) | 208 ± 3010-a | 175 ± 10 | 157 ± 18 | 173 ± 11 | 198 ± 23 | 231 ± 2410-c | 185 ± 11 | 225 ± 1510-c |
| Percentage of events as bursts | 3310-d | 39 | 49 | 42 | 29 | 32 | 39 | 47 |
| Number of bursts | 3210-d | 51 | 38 | 25 | 18 | 2010-e | 29 | 31 |
| Coefficient of variation | 73 ± 610-a | 75 ± 5 | 62 ± 10 | 75 ± 5 | 65 ± 9 | 66 ± 5 | 67 ± 9 | 79 ± 5 |
| Number of cells | 15 | 18 | 12 | 18 | 13 | 10 | 9 | 20 |
SB, SB-277011-A.
↵10-a Each value represents the mean ± S.E.
↵10-b Significantly less than the 1-mg/kg dose, P < .05, ANOVA and Student-Newman-Keul's test.
↵10-c Significantly greater than the 1-mg/kg dose, P < .05, ANOVA and Student-Newman-Keul's test.
↵10-d Each value represents the mean.
↵10-e Significantly less than the 1- and 10-mg/kg doses, P < .05, Kruskal-Wallis ANOVA.