Table 4

Effect of diazepam and SB-277011-A on rotarod performance

Treatment, DoseMean, 120 minS.E.M.Mean, 240 minS.E.M.Mean, 360 minS.E.M.
Vehicle250.3811.27252.2912.58279.559.07
Diazepam195.8821.32248.9311.68264.509.88
SB-277011-A, 9.2 p.o.212.4417.01248.8211.99212.424-150 17.98
SB-277011-A, 27.5 p.o.229.8911.89256.9412.17270.589.22
SB-277011-A, 91.8 p.o.195.444-150 18.01204.4419.06257.734-150 9.15

Significant differences from the vehicle + saline control group were assessed by Kruskal-Wallace one-factor ANOVA followed by one- and two-tailed Mann-Whitney U test.

  • 4-150P < .05.