Receptor binding affinities for SB-277011-A in radioligand binding assays
| Receptor | pKi | Receptor | pKi |
|---|---|---|---|
| hD3 | 7.95 ± 0.02 | rD3 | 7.97 ± 0.04 |
| hD2 | 5.98 ± 0.04 | rD2 | 5.55 ± 0.05 |
| h5-HT1A | <5.3 | h5-HT2A | <5 |
| h5-HT1B | <5.2 | h5-HT2B | 5.89 ± 0.09 |
| h5-HT1D | 5.79 ± 0.06 | h5-HT2C | <5 |
| h5-HT1E | <5 | g-p5-HT4 | <5.3 |
| h5-HT1F | <5.2 | h5-HT6 | <5 |
| h5-HT7 | <5 |
Data are mean ± S.E. from at least three independent determinations using cell lines stably expressing cloned receptors. Receptors and radioligands were hD2, hD3 (human cloned receptors in CHO cells; [125I]iodosulpride); rD2, rD3 (rat cloned receptors in CHO cells; [125I]iodosulpride); h5-HT1A (human cloned receptors in HEK 293 cells; [3H]8-OH-DPAT); h5-HT1B (human cloned receptors in CHO cells; [3H]5-HT); h5-HT1D(human cloned receptors in CHO cells; [3H]5-HT); h5-HT1E (human cloned receptors in CHO cells; [3H]5-HT); h5-HT1F (human cloned receptors in CHO cells; [3H]5-HT); h5-HT2A (human cloned receptors in HEK 293 cells; [3H]ketanserin); h5-HT2B (human cloned receptors in HEK 293 cells; [3H]5-HT); h5-HT2C (human cloned receptors in HEK 293 cells; [3H]mesulergine); gp-5-HT4 (guinea pig hippocampal membranes); h5-HT6(human cloned receptors in HeLa cells; [3H]LSD); h5-HT7 (human cloned receptors in HEK 293 cells; [3H]5-carboxamidotryptamine).