Table 3

The relative Emax(R.Emax) obtained at 20× Kiconcentrations of agonists in Neo cells (± PTX )

DrugR.Emax
Gs Neo (+PTX)Gi Neo (−PTX)
l-Epinephrine0.24  ± 0.02−0.37  ± 0.07
l-Norepinephrine0.18  ± 0.04−0.26  ± 0.03
p-Iodoclonidine0.16  ± 0.04
Oxymetazoline0.05  ± 0.010.37  ± 0.06

The R.Emax values are expressed as a fraction of the UK-14,304 response in receptor-expressing cells. For all agonists, the R.Emax values in Neo cells were indistinguishable from zero after Bonferroni's correction for multiple comparison (P > .05), except for the values reported in this table. A negative value for a Gi response indicates stimulation of cAMP accumulation. Values are mean ± S.E.