Table 2

The activities of ethoxy-, pentoxy-, and benzyloxy-phenoxazone dealkylase in liver microsomes from rats given 25 μg LPS by i.c.v. or i.p. administration

Route of AdministrationTreatmentERODPRODBROD
pmol/mg of protein/min
i.c.v.Saline56.1  ± 6.20.76  ± 0.031.36  ± 0.11
LPS34.8  ± 2.32-a 0.39  ± 0.092-a 0.61  ± 0.142-a
i.p.Saline67.7  ± 4.91.23  ± 0.180.43  ± 0.08
LPS60.5  ± 9.31.22  ± 0.030.31  ± 0.04

Each value is the mean ± S.E., n = 4.

  • 2-a  Significantly different from corresponding control.