Arrythmia score
| n | Minutes of Myocardial Ischemia | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0–3 | 4–6 | 7–9 | 10–12 | 13–15 | 16–18 | 19–21 | 22–24 | 25–27 | 28–30 | Total | ||
| Control | 10 | 0.60 ± 0.16 | 0.30 ± 0.15 | 2.70 ± 0.60 | 2.30 ± 0.56 | 2.40 ± 0.76 | 1.40 ± 0.65 | 0.20 ± 0.13 | 0.40 ± 0.40 | 0.00 ± 0.00 | 0.10 ± 0.10 | 10.40 ± 2.41 |
| TAN-67 | 13 | 0.00 ± 0.00 | 0.15 ± 0.10 | 0.77 ± 0.17 | 0.46 ± 0.22 | 0.38 ± 0.14 | 0.31 ± 0.17 | 0.23 ± 0.17 | 0.15 ± 0.15 | 0.08 ± 0.08 | 0.00 ± 0.00 | 2.38 ± 0.852-150 |
| 5-HD | 10 | 0.50 ± 0.17 | 0.60 ± 0.40 | 2.20 ± 0.57 | 2.30 ± 0.76 | 1.40 ± 0.73 | 1.30 ± 0.67 | 0.50 ± 0.40 | 0.20 ± 0.20 | 0.00 ± 0.00 | 0.00 ± 0.00 | 8.80 ± 2.56 |
| HMR 1098 | 5 | 0.20 ± 0.20 | 0.00 ± 0.00 | 1.20 ± 0.20 | 1.00 ± 0.00 | 0.80 ± 0.20 | 0.20 ± 0.20 | 0.20 ± 0.20 | 0.20 ± 0.20 | 0.20 ± 0.20 | 0.20 ± 0.20 | 4.20 ± 1.07 |
| TAN-67 + 5-HD | 7 | 0.29 ± 0.29 | 0.71 ± 0.29 | 1.29 ± 0.29 | 0.57 ± 0.30 | 0.57 ± 0.30 | 0.57 ± 0.20 | 0.29 ± 0.18 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 4.71 ± 1.11 |
| TAN-67 + HMR 1098 | 6 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.33 ± 0.21 | 0.50 ± 0.22 | 0.33 ± 0.21 | 0.33 ± 0.21 | 0.17 ± 0.17 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 1.67 ± 0.802-150 |
Values given as mean ± S.E. Arrythmia score calculated as stated in Materials and Methods. 5-HD, 5 minutes before either control or TAN-67 treatment protocol; HMR 1098, 3 mg/kg, 5 minutes before either control or TAN-67 treatment protocol.
Statistical significance was determined for total arrhythmias only,
↵2-150 P < .05 versus control.