Table 1

Effect of resveratrol on [3H]AA release and PGE2 synthesis induced by FCS or PDGF

[3H]AA ReleasedPGE2
% pg/1000 cells
Control4.9  ± 0.313  ± 1.3
FCS38.2  ± 2.1146  ± 9
FCS + resveratrol16.7  ± 2.31-150 38  ± 41-150
FCS + curcumin15.1  ± 1.31-150 42  ± 31-150
FCS + quercetin18.1  ± 1.61-150 51  ± 41-150
PDGF35.6  ± 1.7115  ± 7
PDGF + resveratrol17.2  ± 1.21-150 41  ± 51-150
PDGF + curcumin15.1  ± 1.41-150 37  ± 31-150
PDGF + quercetin13.2  ± 1.31-150 49  ± 41-150

Fibroblasts (10,000/cm2) were incubated with FCS (10%) or PDGF (10 ng/ml) in the absence or presence of resveratrol (30 μM), curcumin (10 μM), or quercetin (10 μM) for 2 h. Measurements were performed in triplicate and are expressed as the mean ± S.E. of two experiments.

  • 1-150P < .05 compared with nontreated group.