Table 1

Summary of the interaction of S33084 compared with GR218,231 and L741,626, at D3- versus D2 receptors

pKiRatio D2:D3pKiRatio D2:D3
hD3hD2D3D2
S330849.617.521208.726.8090
GR218,2319.017.23608.676.61110
L741,6267.218.420.076.467.520.09

Data for cloned human hD3 and hD2 receptors are fromMillan et al. (2000b) and those for cloned rat D3 and native, striatal D2 receptors are from Cussac et al. (2000). Radioligands were [125I]iodosulpride for hD3, hD2, and cloned rat D3 sites, and [3H]spiperone for D2 sites.