Interaction of S33084, GR218,231, and L741,626 at cloned hD3- versus hD2-receptors
| Drug | ← [125I]iodosulpride → | ← [3H]spiperone → | ← [35S]GTPγS → | ||||||
|---|---|---|---|---|---|---|---|---|---|
| pKihD3 | pKi hD2 | Ratio D2:D3 | pKihD3 | pKi hD2 | Ratio D2:D3 | pKbhD3 | pKb hD2 | Ratio D2:D3 | |
| S33084 | 9.59 ± 0.10 | 7.54 ± 0.20 | 120 | 9.40 ± 0.09 | 7.28 ± 0.17 | 125 | 9.61 ± 0.11 | 7.75 ± 0.05 | 66 |
| GR218,231 | 8.96 ± 0.18 | 7.18 ± 0.03 | 60 | 8.87 ± 0.03 | 6.86 ± 0.10 | 100 | 9.02 ± 0.05 | 7.27 ± 0.15 | 65 |
| L741,626 | 7.22 ± 0.12 | 8.39 ± 0.07 | 0.07 | 7.06 ± 0.01 | 8.18 ± 0.06 | 0.06 | 7.38 ± 0.08 | 8.74 ± 0.01 | 0.04 |
Values (pKi and pKb) are mean ± S.E. of at least three independent determinations performed in triplicate. Ratio is calculated from Kiand Kb values.