Table 1

Effect of naloxone on high-affinity [³H]dopaminergic uptake by midbrain neurons after LPS treatment

Treatment Time	LPS	Dopamine Uptake
Treatment Time	LPS	LPS Alone	1 μM Nal + LPS
h	ng/ml	% control
9	0	100.0 ± 3.0
	0.1	95.6 ± 20.2
	1	95.0 ± 12.7
	10	96.0 ± 11.3
	100	86.3 ± 19.9
16	0	100.0 ± 10.8	93.6 ± 17.4
	0.1	86.5 ± 7.7	93.5 ± 4.1
	1	67.8 ± 10.8^1-150	96.0 ± 8.5^†
	10	58.1 ± 14.4^**	88.6 ± 5.4^†
	100	50.1 ± 5.1^**	85.0 ± 4.8^† ^†
24	0	102.6 ± 4.9	114.8 ± 5.5
	0.1	64.8 ± 8.1^**	92.3 ± 5.4^†
	1	45.6 ± 7.8^**	80.5 ± 7.8^† ^†
	10	43.3 ± 5.7^**	75.4 ± 9.3^†
	100	35.6 ± 5.1^**	68.5 ± 4.0^† ^†
48	0	100.5 ± 5.2	104.3 ± 3.5
	0.1	66.7 ± 8.3^1-150	90.0 ± 3.9^†
	1	41.4 ± 9.7^**	81.4 ± 0.3^†
	10	34.5 ± 12.5^**	63.7 ± 5.1^†
	100	31.1 ± 10.6^**	65.0 ± 8.6^†

The results are expressed as the percentage of the control uptake of dopaminergic and are the mean ± S.E. of three or four experiments performed in triplicate. The value for control group was 449.6 ± 67.4 fmol of dopaminergic/well.

Nal, naloxone.
↵1-150 P < .05 and ** P < .005, compared with the untreated control cultures, respectively; ^† P < .05 and ^†^† P < .005, compared with the corresponding LPS-treated cultures, respectively.