Incubation Time | 90 min | 25 h | ||
---|---|---|---|---|
Insulin, nmol/l | 30 | 100 | ||
% Ethanol (v/v) | 0 | 0.8 | 0 | 0.5 |
% DMSO (v/v) | 0 | 0.4 | 0 | 0.1 |
CO2 release (nmol glucose/g/h) | 367 ± 54 | 607 ± 1291-150 | 2984 ± 159 | 2572 ± 139 |
Lactate release (μmol/g/h) | 11.9 ± 0.7 | 14.8 ± 0.4** | 11.7 ± 0.9 | 12.9 ± 0.8 |
Glucose transport (cpm/mg/h) | 716 ± 16 | 672 ± 24 | 759 ± 56 | 733 ± 47 |
Glycogen synthesis (μmol glucose/g/h) | 7.16 ± 0.57 | 5.84 ± 0.51 | 3.42 ± 0.19 | 3.16 ± 0.15 |
Glycogen content (μmol glucosyl U/g) | 15.5 ± 0.4 | 14.5 ± 0.7 | 11.8 ± 0.7 | 10.7 ± 0.6 |
Rates of insulin-stimulated glucose metabolism in soleus muscle strips from healthy Sprague-Dawley rats were incubated in the absence or presence of organic solvent concentrations as used throughout this study. Means ± S.E.; n = 5 or 6 each.
↵1-150 P < .05, ** P < .01 versus control without organic solvents.