Comparison of nateglinide, glibenclamide, and repaglinide under various assay conditions
| Parameter Measured | Assay System | Nateglinide | Glibenclamide | Repaglinide |
|---|---|---|---|---|
| Rate of compound release from receptor | Membrane receptor preparations | Fast (seconds) | Slow (minutes) and very slow (biphasic release) | Slow (minutes) |
| Rate of reversal of KATP channel inhibition by compounds | Intact β-cells | Moderate | Slower | Slowest |
| Rate of reversal of insulin release stimulated by compounds | Perifused islets | Fast (Jijakli et al., 1997) | Slow (Lebrun and Malaisse, 1992) | Slow (Jijakli et al., 1996) |