Table 4

Time course of the KATP channel activity-blocking effects

Compoundt1/2(on)4-at1/2(off)4-a
min min
Nateglinide4.1  ± 0.335  ± 3.8
Glibenclamide4.2  ± 0.468  ± 4.0
Repaglinide12  ± 2.4175  ± 1.0
  • 4-a These values represent the time required to observe 50% inhibition of KATP channel activity after addition of the indicated compound ([t1/2(on) (in minutes))] or the time required for return to 50% inhibition of KATP channel activity after removal of the compound [t1/2(off) (in minutes)].