Table 3

Summary of [3H]glibenclamide dissociation kinetic experiments with various competitive ligands

Competitive Ligandk1Fraction 1 ± S.E.M.k2Fraction 2 ± S.E.M.
min−1a ± S.E.M. min−1 ± S.E.M.
Glibenclamide0.011  ± 0.0040.46  ± 0.0480.23  ± 0.0420.54  ± 0.054
Nateglinide0.011  ± 0.0030.46  ± 0.0320.27  ± 0.0320.54  ± 0.035
Repaglinide0.011  ± 0.0010.44  ± 0.00030.22  ± 0.0080.56  ± 0.0003

Fractions 1 and 2 refer to the fractional magnitude for each component in the biphasic release model. Data are obtained from three separate experiments.

  • 3-a Dissociation rate constants for the two phases of [3H]glibenclamide release.