Table 1

Binding parameters with RIN-m5F cell membranes

CompoundIC50Ki Hill Coefficient
nM ± S.E.M.1-a nM ± S.E.M. Slope ± S.E.M.
Glibenclamide1.1  ± 0.20.39  ± 0.070.88  ± 0.09
Glimepiride1.9  ± 0.10.67  ± 0.040.58  ± 0.0011-b
Repaglinide5.0  ± 0.61.8  ± 0.20.60  ± 0.0091-b
Glipizide17  ± 0.96.0  ± 0.30.85  ± 0.009
Nateglinide490  ± 50170  ± 180.98  ± 0.06
l-Isomer of nateglinide12,000  ± 9004,200  ± 3200.97  ± 0.05
Tolbutamide76,000  ± 960027,000  ± 3,4000.95  ± 0.09

  • ↵1-a Values determined from three separate experiments.

  • ↵1-b Hill coefficients differ significantly (P < .05) from other values.