CYP Isoform | Parameter | Concentration of Control Microsomes Added3-c | |
---|---|---|---|
0 | 750 | ||
μg/ml | |||
2C193-a | V max 3-c | 4.22 ± 0.2 | 4.01 ± 0.3 |
K m 3-d | 10.22 ± 1.5 | 35.8 ± 6.4 | |
K s 3-d | 766 ± 158 | 1661 ± 702 | |
3A43-b | V max 3-c | 3.09 ± 0.09 | 3.5 ± 0.11 |
S50 3-d | 84.6 ± 4.4 | 150.4 ± 7.9 | |
A | 1.91 ± 0.2 | 1.74 ± 0.1 |
Values are mean ± S.E. of parameter estimates.Km and S50 estimates are apparent values based on total (added) substrate concentrations.