Table 1

Effect of orange juice and extracts on the uptake of [3H]vinblastine by Caco-2 cells

Cell/Medium Ratio
% control
Control100 ± 4.3
 +50% orange juice178 ± 5.51-a
 +50% ethyl acetate extract238 ± 2.81-a
 +50% diethyl ether extract203 ± 141-a
 +50% methylene chloride extract198 ± 4.51-a

Uptake experiments of 10 nM [3H]vinblastine by Caco-2 cells were performed in the absence or presence of orange juice and extracts for 60 min. Control value was 19.5 ± 2.05. Each value represents the mean ± S.E. of four experiments.

  • 1-a Significant differences from control,P < .05