Table 6

Comparison between predicted value and observed value of increasing ratios of plasma concentration of MDZ

Inhibitor	R_p 1 +C_pf/K_i	R_H 1 +C_Hf/K_i	AUC′/AUC
EM	1.04	1.73	2.02
DLZ	1.06	1.06	1.64
VER	1.02	1.05	1.30

The increasing ratios R_p and R_H were calculated fromC_pf and C_Hf. AUC′/AUC is observed value calculated from Fig. 4.