Table 5

Effect of various drugs on CYP

Uncomplexed CYPComplexed CYPTotal CYP
nmol/mg protein
Control 15-a 1.100  ± 0.050N.D.1.106  ± 0.053
DLZ
 2-h infusion1.097  ± 0.121N.D.1.102  ± 0.127
 5-h infusion1.141  ± 0.150N.D.1.139  ± 0.136
VER
 2-h infusion1.150  ± 0.057N.D.1.146  ± 0.051
 5-h infusion1.055  ± 0.132N.D.1.064  ± 0.133
Control 25-b 1.086  ± 0.038N.D.1.093  ± 0.043
EM
 2-h infusion1.136  ± 0.168N.D.1.161  ± 0.161
 5-h infusion1.090  ± 0.138N.D.1.102  ± 0.123
Control 35-c 1.069  ± 0.132N.D.1.066  ± 0.120
EM, 3 days0.765  ± 0.1030.473 ± 0.0371.222  ± 0.102
TAO, 3 days0.965  ± 0.0501.859 ± 0.1312.800  ± 0.173

Values are means ± S.D. (n = 5).

  • N.D., not determined.

  • ↵5-a Saline i.v.

  • ↵5-b Phosphate buffer i.v.

  • ↵5-c Corn oil i.p.