Pharmacokinetic parameter of MDZ after intraportal injection in the absence (−) or the presence (+) of EM, DLZ, or VER
| −EM | +EM | −DLZ | +DLZ | −VER | +VER | |
|---|---|---|---|---|---|---|
| AUC0–∞(μg·min/ml) | 102.4 ± 8.0 | 207.4 ± 24.4** | 100.4 ± 8.0 | 164.8 ± 39.23-150 | 100.9 ± 6.0 | 130.5 ± 35.23-150 |
| f B·CLH,int (ml/min/kg) | 101.0 ± 7.7 | 48.6 ± 5.5** | 100.0 ± 7.7 | 62.9 ± 13.8** | 100.0 ± 4.7 | 81.5 ± 23.2 |
| t 1/2β (min) | 28.3 ± 2.1 | 42.0 ± 12.03-150 | 24.1 ± 0.9 | 32.3 ± 5.33-150 | 24.5 ± 0.9 | 29.7 ± 6.9 |
Values are means ± S.D. (n = 4). Significant differences from −EM, −DLZ, or −VER were determined by Student'st test.
↵3-150 P < .05; ** P < .01.