Table 1

Biodistribution of ^99mTc-labeled HYNIC-PEG liposomes in rats that received weekly injections, 4-h postinjection

Organ	%ID (mean of five values ± S.E.)
Organ	1st Injection	2nd Injection	3rd Injection	4th Injection
Blood	52.54 ± 3.68	0.55 ± 0.05^**	8.50 ± 2.93^**	51.04 ± 7.30^NS
Spleen	2.19 ± 0.17	6.25 ± 0.36^**	5.31 ± 0.69^**	2.29 ± 0.50^NS
Liver	8.06 ± 0.79	46.41 ± 3.20^**	41.52 ± 1.60^**	14.82 ± 5.84^NS
Muscle	9.61 ± 2.26	0.92 ± 0.02^1-150	1.58 ± 0.40^**	6.25 ± 0.96^NS
Bone	7.82 ± 0.98	3.73 ± 0.88^1-150	3.68 ± 1.41^1-150	5.70 ± 0.90^NS
Lung	0.73 ± 0.08	0.13 ± 0.02^**	0.26 ± 0.08^**	0.66 ± 0.13^NS
Intestine	0.03 ± 0.01	0.04 ± 0.01^NS	0.01 ± 0.00^NS	0.02 ± 0.00^NS
Kidney	1.52 ± 0.10	0.39 ± 0.04^**	0.55 ± 0.07^**	1.09 ± 0.43^NS

NS, not significant.
↵1-150 P < .05; ** P < .01. Depicted P values (two-tailed unpaired t test) refer to differences between the first injection and, respectively, the second, third, and fourth injection.