Table 1

PK parameters of SB-249417 after i.v. administration to male Cynomolgus monkeys

Dose	Animal No.	C₁	λ₁	C₂	λ₂	k₁₀	t_1/2-λ1	t_1/2-λ2	V_c	V_ss	CL
		μg/ml^1-150	h⁻¹	μg/ml^1-150	h⁻¹	h⁻¹	h	h	ml/kg	ml/kg	ml/kg
1 mg/kg	3	15.9	0.0817	10.4	0.00946	0.0204	8.49	73.3	39.9	72.3	0.772
	4	12.3	0.0676	6.85	0.00820	0.0186	10.3	84.5	55.8	106	1.00

3 mg/kg	5	52.6	0.0427	29.1	0.00717	0.0155	16.2	96.6	36.7	60.0	0.543
	6	60.2	0.0369	25.5	0.00606	0.0147	18.8	114	33.3	60.7	0.466

10 mg/kg	1	110	0.124	169	0.00988	0.0155	5.59	70.2	36.5	53.9	0.537
	2	121	0.0581	131	0.00659	0.0115	11.9	105	40.9	63.5	0.453

Mean			0.0685		0.00789	0.0160	11.9	90.6	40.5	69.4	0.629
S.D.			0.0317		0.00155	0.0312	4.90	17.6	7.96	18.9	0.215