Table 1

Side effects induced by various cholinergic agonists

Compound	Frequency Observed 10 min after Drug		Peak Hypothermia
Compound	CHROMO	LACRI	SALIV	TREM	Δ Temperature	After Drug	Hypothermia Duration
mg/kg i.p.	%		°C	min
Oxotremorine
0.3 (n = 10)	0	10	40^1-150	20	−1.11^1-160	20	10–60^1-a
1.0 (n = 10)	90^1-150	90^1-150	90^1-150	80^1-150	−1.42^1-160	20	10–60^1-a
3.0 (n = 10)	50^1-150	70^1-150	70^1-150	80^1-150	−1.41^1-160	60^1-a	20–60^1-a
Pilocarpine
3.0 (n = 8)	12.5	25	0	0	−0.80^1-160	30	10–60
10 (n = 8)	87.5^1-150	87.5^1-150	62.5^1-150	0	−1.65^1-160	30	10–90^1-a
30 (n = 8)	100^1-150	100^1-150	100^1-150	0	−1.90^1-160	90^1-a	30–90^1-a
Arecoline
3.0 (n = 8)	0	0	12.5	0	−1.15^1-160	10	10–30
10 (n = 8)	0	0	100^1-150	0	−1.40^1-160	10	10–30
30 (n = 8)	0	62.5^1-150	100^1-150	37.5	−1.49^1-160	10	10–30
WAY-132983
3.0 (n = 8)	0	0	12.5	0	−1.22^1-150	30	10–60
10 (n = 8)	0	0	62.5^1-150	0	−2.05^1-160	60	10–120
30 (n = 8)	0	0	100^1-150	12.5	−1.49^1-160	120	30–120
Xanomeline
0.3 (n = 8)	0	0	0	0	−0.11	30
3.0 (n= 8)	0	0	0	0	−0.40	10
10 (n= 7)	0	0	75^1-150	0	−0.58^1-160	30	10–30
30 (n = 8)	0	0	87.5^1-150	0	−2.03^1-160	30	10–90^1-a
mg/kg p.o.
WAY-132983
3.0 (n = 8)	12.5	12.5	25	0	−0.67^1-160	30	30
10 (n = 8)	0	0	50^1-150	0	−1.02^1-160	60	30–60
30 (n = 8)	12.5	12.5	87.5^1-150	0	−1.52^1-160	120	30–120
Xanomeline
3.0 (n = 8)	0	0	0	0	+0.15	10
10 (n = 8)	0	0	50^1-150	0	−0.07	60^1-a
30 (n = 8)	0	0	37.5	0	−0.11	10