Table 5

Average concentration of ISIS 5132 or ISIS 13650 in tissues after alternate day treatment for 3 weeks5-b

Organ5-aOligonucleotide Concentration
ISIS 5132ISIS 13650
μg/g
Kidney229  ± 1151086  ± 365
Liver69  ± 18381  ± 83
  • 5-a Data represent means ± S.D. from three to six animals per group.

  • 5-b Mice were treated with a 25-mg/kg dose of the respective oligonucleotide for 21 days by i.v. injection. Oligonucleotide concentration was assayed by capillary gel electrophoresis.