Table 3

Incidence and severity of multiorgan cell infiltrate in various strains of mice after i.v. administration of ISIS 1082

Number of Doses3-aCD-1 MiceC3H MiceC57 Mice
50 mg/kg ISIS 1082
11/30/30/3
minimal
30/32/30/3
mild
72/33/33/3
mild–moderatemild–moderateminimal
  • 3-a Doses were administered daily by i.v. injection.