Table 1

Expression of CYP3A activity in di-OH vitamin D3-treated Caco-2 cells

6β-OH-Testosterone Formed/4 h
ApicalBasolateralTotal
nmol
Di-OH vitamin D3-treated cells0.61  ± 0.080.57  ± 0.101.18  ± 0.18
Untreated cells0.01  ± 0.020.01  ± 0.020.02  ± 0.03
Di-OH vitamin D3 + 1 μM ketoconazole0.09  ± 0.020.00  ± 0.000.09  ± 0.22