Table 3

Maximum percentage of drug-lever responding and maximum suppression of response rate by drugs in zolpidem-trained squirrel monkeys

DrugDoseMaximum Zolpidem-Lever RespondingMaximum Suppression of Response Rate (% control)
mg/kg %
Cyproheptadine0.30–5.645  (6.6)9.3  (3.0)
Baclofen0.10–3.012  (8.3)23  (1.2)
Muscimol3-a 0.030–0.5626  (26)56  (1.9)
Buspirone0.030–0.5639  (12)5.2  (0.20)
Diphenhydramine0.30–5.61.0  (0.30)22  (3.8)
Flumazenil0.010–1.00  (0)25  (3.8)

Data are means (S.E.M.) based on data from four monkeys.

  • 3-a Doses higher than 0.56 mg/kg were not tested due to toxicity noted previously in squirrel monkeys (Spealman, 1985).