Table 1

Effects of drug treatments on Icomp and ID currents

Icomp(Inactivation)ID(Activation)ID (Inactivation)N
Peak IAτV1/2Peak IDτV1/2
nA ms mV nA ms mV
Control-comp.1.24  ± 0.1051.2  ± 2.9−71.3  ± 3.10.64  ± 0.0998.2  ± 7.4−39.9  ± 3.543
4-AP1.15  ± 0.0824.4  ± 3.11-a −71.5  ± 3.70.24  ± 0.061-a 1-b 1-b 21
DTX1.13  ± 0.0725.4  ± 4.91-a −72.1  ± 4.80.22  ± 0.051-a NCNC8
WIN1.29  ± 0.0821.2  ± 3.41-a −54.3  ± 4.41-a 0.25  ± 0.031-a NCNC12
WIN + DTX1.27  ± 0.0618.4  ± 5.21-a −53.2  ± 2.41-a 0.21  ± 0.031-a NCNC7
PTX1.22  ± 0.0950.4  ± 1.6−70.9  ± 3.80.60  ± 0.0596.1  ± 6.5−40.9  ± 4.89
PTX + WIN1.23  ± 0.0751.1  ± 4.1−71.2  ± 2.30.59  ± 0.0899.2  ± 8.3−38.2  ± 3.99
PTX + DTX1.19  ± 0.0824.1  ± 3.71-a −70.9  ± 2.90.24  ± 0.041-a NCNC4
GTPγS1.29  ± 0.0928.3  ± 4.01-a −60.1  ± 4.01-a 0.30  ± 0.081-a NCNC8
GTP + WIN1.32  ± 0.041-a 22.5  ± 1.51-a −58.5  ± 2.91-a 0.31  ± 0.071-a NCNC8
8-br-cAMP1.04  ± 0.091-a 65.3  ± 2.41-a −85.3  ± 4.21-a 0.81  ± 0.081-a NC−33.7  ± 4.67
cAMP + WIN1.05  ± 0.081-a 64.2  ± 2.11-a −85.1  ± 3.61-a 0.80  ± 0.061-a NC−34.6  ± 3.97
IP-201.27  ± 0.0928.9  ± 3.21-a −58.2  ± 4.71-a 0.28  ± 0.091-a NCNC6
IP-20 + WIN1.30  ± 0.1126.3  ± 2.71-a −55.9  ± 3.41-a 0.24  ± 0.071-a NCNC6
Rp-cAMPS1.29  ± 0.0634.7  ± 3.9−63.2  ± 2.11-a 0.41  ± 0.051-a NCNC6
Rp + WIN1.31  ± 0.071-a 22.8  ± 4.31-a −55.8  ± 3.31-a 0.27  ± 0.071-a NCNC6
Cat.S.1.08  ± 0.061-a 58.9  ± 2.71-a −81.3  ± 3.21-a 0.77  ± 0.101-a 101.3  ± 8.8−33.2  ± 4.94
Cat.S. + WIN1.06  ± 0.071-a 56.2  ± 3.3−80.7  ± 2.81-a 0.80  ± 0.091-a 98.8  ± 7.5−34.3  ± 3.84
OA1.05  ± 0.071-a 61.3  ± 3.51-a −83.0  ± 2.91-a 0.79  ± 0.071-a 99.2  ± 8.1−32.8  ± 4.34
OA + WIN1.07  ± 0.061-a 60.2  ± 2.91-a −82.1  ± 3.01-a 0.77  ± 0.061-a 94.5  ± 7.2−33.3  ± 5.34
SR1.22  ± 0.0950.6  ± 3.3−70.9  ± 3.10.59  ± 0.0999.3  ± 8.2−39.1  ± 3.98
SR + WIN1.23  ± 0.0751.5  ± 2.9−72.2  ± 4.50.58  ± 0.0696.2  ± 7.7−40.6  ± 4.18
  • 1-a Measures were significantly different from control,F1,95 > 7.00, p < .01.

  • 1-b NC, τ and V1/2 could not be calculated due to reduction in ID amplitude and change in slope of Boltzmann curve; 4-AP values were used as baseline for pharmacological subtraction.