Table 2

Cannabinoid ligand-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cell lines expressing CB1 or CB1/2(TMIII)

CompoundsCB1CB1/2(TMIII)
EC50Maximum InhibitionEC50Maximum Inhibition
nM % nM %
CP 55,9405.5  ± 2.97215.8  ± 6.878
WIN 55,212-238.9  ± 8.2687.0  ± 0.697
JWH 01814.7  ± 3.9794.7  ± 0.870

Results are presented as mean ± S.E. of EC50 values from at least two experiments performed in duplicate.