mAb3A4a-mediated inhibition of the metabolism of marker substrates by human liver microsomes
| Substrate | Concentration2-a | % Control2-b (+ mAb) | Substrate | Concentration | % Control (+ mAb) |
|---|---|---|---|---|---|
| μM | μM | ||||
| Testosterone | 250 | 1.97 ± 0.05 | Bufuralol | 50 | 115.2 ± 0.23 |
| (CYP3A4)2-c | 75 | 2.60 ± 0.00 | (CYP2D6) | 15 | 111.9 ± 9.08 |
| 25 | 4.55 ± 0.06 | 5 | 106.8 ± 14.5 | ||
| Chlorzoxazone | 500 | 104.7 ± 6.37 | Diclofenac | 100 | 108.3 ± 1.16 |
| (CYP2E1) | 100 | 103.6 ± 0.56 | (CYP2C9) | 30 | 113.1 ± 1.14 |
| 20 | 119.8 ± 0.3 | 10 | 125.7 ± 0.15 | ||
| (S)-Mephenytoin | 400 | 99.5 ± 1.41 | Phenacetin | 1000 | 101.9 ± 1.75 |
| (CYP2C19) | 120 | 94.6 ± 4.33 | (CYP1A2) | 150 | 107.5 ± 1.12 |
| 40 | 96.4 ± 1.99 | 25 | 113.9 ± 0.91 |