Table 4

EC50 values for morphine on μOR/Gαi1-expressing cells

Timei1(WT)i1(G183S)
min nM
3017.4  ± 2.710.5  ± 3.14-150
6022.8  ± 2.713.6  ± 3.14-150
12031.8  ± 3.019.2  ± 3.24-150
18031.6  ± 1.920.1  ± 2.74-150
24037.0  ± 1.922.4  ± 3.14-150
30039.5  ± 2.823.6  ± 3.24-150
36043.6  ± 4.125.0  ± 3.94-150
42048.9  ± 4.427.8  ± 4.14-150

Data are expressed as mean ± S.D. (n = 3). Data are representative of at least duplicate experiments.

  • 4-150 p ≤ .05, compared with the corresponding Gαi1(WT) sample value.