Table 1

Structure and physicochemical properties of the model drugs  

Table 1
AlfentanilCimetidine
pK a 1-a 6.56.8
pK a,calc 1-b 5.86.0
logP1-c 2.160.40
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  • 1-a Experimentally determined pKavalues (from Craig, 1990).

  • 1-b Theoretically calculated pKa values (seeMaterials and Methods).

  • 1-c Octanol/water partition coefficients (from Craig, 1990).