IC50 values for inhibition of [3H]serotonin uptake into mouse cortex synaptosomes or human platelets. Data are means ± S.D. of six determinations
| Substance | IC50 | |
|---|---|---|
| Synaptosomes | Platelets | |
| nM | ||
| Citalopram | 1.1 ± 0.2 | 1.2 ± 0.5 |
| Clomipramin | 1.0 ± 0.1 | 0.2 ± 0.1 |
| Hyperforin | 1234.6 ± 112.4 | 887.0 ± 153.9 |
| Monensin | 47.8 ± 16.3 | 159.5 ± 40.6 |