Table 2

Kinetic analyses of the effects of citalopram, hyperforin, and monensin on [3H]serotonin uptake into mouse cortex synaptosomes. Data are means ± S.D. of six determinations.

KmVmax
nM pmol/min/mg
Control12.72  ± 5.010.105  ± 0.044
Citalopram (1 nM)29.24  ± 5.252-160 0.106  ± 0.074
Control11.90  ± 2.070.191  ± 0.034
Hyperforin (2 μM)9.93  ± 0.592-150 0.083  ± 0.0322-160
Control13.78  ± 2.500.133  ± 0.030
Monensin (100 nM)14.72  ± 3.940.065  ± 0.0092-160
  • 2-150p < .05.

  • 2-160p < .001 using unpaired t-test.