Table 1

IC50 for specific [3H]serotonin uptake and for specific [3H]paroxetine binding. Data are means ± S.D. of six experiments

SubstanceIC50
[3H]Paroxetine Binding[3H]Serotonin UptakeRatio1-a
nM
Clomipramine1.9  ± 0.41.0  ± 0.11.9
Sertraline3.3  ± 0.32.1  ± 1.01.6
Citalopram4.1  ± 0.61.1  ± 0.23.7
Fluvoxamine13.5  ± 3.710.9  ± 5.61.2
Fluoxetine26.9  ± 0.610.4  ± 5.12.6
Monensin>100047.8  ± 16.3
Desipramine672.3  ± 171.6214.3  ± 89.53.1
Hyperforin19,528  ± 6,9831,357  ± 17114.4
  • 1-a IC50 [3H]paroxetine binding/IC50 [3H]serotonin uptake.