Table 2

Effect of LPS-induced hypophagia on liver and kidney CYP mRNA expression

TreatmentSalineLPSPair Fed
% control
Kidney
 CYP4A10100  ± 11(8)234  ± 302-a 2-b (9)92  ± 6(9)
 CYP4A14100  ± 8(9)243  ± 282-a 2-b (9)70  ± 42-a (9)
Liver
 CYP4A10100  ± 13(9)38  ± 72-a 2-b (8)141  ± 142-a (9)
 CYP4A14100  ± 14(9)81  ± 152-b (9)183  ± 242-a (9)
 CYP2C29100  ± 9(9)53  ± 92-a 2-b (9)141  ± 122-a (9)
 CYP3A11100  ± 9(9)39  ± 82-a 2-b (9)91  ± 17(9)
 CYP2A52-c 100  ± 10(9)20  ± 72-a 2-b (9)213  ± 282-a (7)

Mice were treated with LPS and pair fed as described in Table 1. Numbers represent the mean ± S.E. of each group. The number of animals is given in parentheses. There were nine animals in each experimental group: some samples were omitted from analyses because of Northern blot artifacts in the area of the sample or because the value was >2 S.D. from the group mean.

  • 2-a Significantly different from saline-treated group,P < .05.

  • 2-b Significantly different from pair-fed group P < .05.

  • 2-c Mann-Whitney U test was used for CYP2A5.