Table 1

Food intake in saline- and LPS-treated mice

PeriodnFood intake
SalineLPSLPS/Saline
g/mouse
8:00 AM to 2:00 PM60.44  ± 0.080.07  ± 0.040.16
2:00 to 8:00 PM60.90  ± 0.250.31  ± 0.080.34
8:00 PM to 2:00 AM33.11  ± 0.320.47  ± 0.250.15
2:00 to 8:00 AM31.01  ± 0.060.80  ± 0.320.79
Total35.32  ± 0.421.59  ± 0.250.30

Mice were housed in groups of three per cage. Animals in the saline- and LPS-treated groups were given free access to food, and food intake of each cage was measured at 6-h intervals. Mice in the pair-fed group were fed at the same intervals as the LPS group to approximate the eating pattern of the treated mice. All animals had free access to water. Food intake values are means of six cages (n = 18 mice) for the 8:00 AM to 2:00 PM and 2:00 to 8:00 PM periods and three cages (n = 9) for the 8:00 PM to 2:00 AM, 2:00 to 8:00 AM, and 24-h (total) periods. Values in the LPS/saline column are ratios of the mean food intake of the two groups.