Morphine pharmacokinetics in male monkeys and in ovariectomized females without E2β treatment or during treatment with 0.01 mg/kg/day E2β
| Males | OVX Females | ||
|---|---|---|---|
| No E2β | 0.01 E2β | ||
| C max(ng/ml) | 2,628 (277) | 2,510 (493) | 2,230 (216) |
| T max (min) | 25.0 (10.9) | 15.0 (5.3) | 22.5 (9.2) |
| AUC (ng/ml/ min) | 253,749 (16,794) | 214,454 (25,586) | 188,646 (16,407) |
All values show the mean (S.E. in parentheses) in three monkeys (males) or four monkeys (females). Values shown are the peak plasma morphine concentration (Cmax), time to peak plasma morphine concentration (Tmax), and the AUC.