IC50 values of rofecoxib, celecoxib, meloxicam, diclofenac, and indomethacin in human whole blood COX-1 and COX-2 assays
| COX-1 IC50 | Donor | COX-2 IC50 | Donor | COX-1/COX-2 Ratio of IC50 | |
|---|---|---|---|---|---|
| μM | n | μM | n | ||
| Rofecoxib | 18.8 ± 0.9 | 211 | 0.53 ± 0.02 | 614 | 35.5 |
| Celecoxib | 6.3 ± 1.0 | 9 | 0.96 ± 0.24 | 12 | 6.6 |
| Meloxicam | 1.4 ± 0.4 | 6 | 0.70 ± 0.28 | 5 | 2.0 |
| Diclofenac | 0.15 ± 0.04 | 10 | 0.05 ± 0.01 | 16 | 3.0 |
| Indomethacin | 0.19 ± 0.02 | 36 | 0.44 ± 0.07 | 34 | 0.4 |