Table 4

Comparison of scaled CLint and Vmax for both pathways of DEM metabolism in microsomes and hepatocytes

PathwayParameterMicrosomesHepatocytesMicrosomes/Hepatocytes
DORCLint(ml/min/SRW)30234.18.9
DOR V max(μmol/min/SRW)1.250.721.7
MEMCLint(ml/min/SRW)16.891.70.2
MEM V max(μmol/min/SRW)2.282.231