Table 3

Comparison of target steady-state concentration, with corresponding loading dose and infusion rate, and steady-state concentrations achieved

Target Steady-State ConcentrationLoading DoseInfusion RateObserved Steady-State ConcentrationCL
mg/l mg/kg mg/h/kg mg/l ml/min/SRW
0.59.98.80.46  ± 0.0481.0  ± 8.4
114.811.70.93  ± 0.2154.0  ± 11.9
1.529.723.41.56  ± 0.3064.0  ± 12.0