Table 4

Effect of various compounds on uptake of [¹⁴C]HSR-903 (50 μM) by K562 and K562/ADM cells

Inhibitor	Concentration	Uptake
Inhibitor	Concentration	K562	K562/ADM
	mM	μl/10⁶ cells
Control		11.1 ± 0.4	4.1 ± 0.3
HSR-903	5	19.5 ± 2.1	17.6 ± 0.6^4-a
Cyclosporin A	0.01	11.1 ± 1.4	9.6 ± 0.3^4-a
Anionic compounds
Control		9.5 ± 0.8	3.2 ± 0.1
Probenecid	10	7.2 ± 0.5	2.3 ± 0.1^4-a
Valproic acid	10	7.1 ± 0.4	2.4 ± 0.1^4-a
p-Aminohippuric acid	10	9.1 ± 0.6	3.2 ± 0.1
Nicotinic acid	10	9.3 ± 0.6	3.0 ± 0.1
DIDS	1	24.5 ± 0.8^4-a	25.5 ± 1.7^4-a
SITS	1	16.3 ± 2.9^4-b	19.1 ± 2.3^4-a
l-Lactic acid	10	10.7 ± 0.1	3.5 ± 0.2
Cationic compounds
Control		10.5 ± 1.3	3.1 ± 0.2
Tetraethylammonium	10	8.0 ± 1.2	3.1 ± 0.1
Quinidine	0.5	7.4 ± 0.9	7.4 ± 2.3^4-a
Metabolic inhibitor
2,4-Dinitrophenol	1	8.8 ± 1.4	7.3 ± 0.5^4-a
NaN₃+NaF	10	9.9 ± 1.1	7.3 ± 0.6^4-a

The uptake of [¹⁴C]HSR-903 by K562 and K562/ADM cells was measured at 37°C for 60 min. Each value represents the mean ± S.E. from four experiments.
↵4-a p < .01 versus control.
↵4-b p < .05 versus control, by ANOVA.