Metabolism of various model substrates by CYP2F2
| Substrate | Substrate for: | Activity | |
|---|---|---|---|
| pmol/min/nmol CYP-450 | pmol/min/nmol CYP2F2 | ||
| Ethoxyresorufin | CYP1A1 | 37,0002-a | 2.5 ± 0.3 |
| Pentoxyresorufin | CYP2B | 11802-b–31502-c | 2.1 ± 0.4 |
| p-Nitrophenol | CYP2E1 | 20102-d–40002-e | 2510 ± 146.1 |
Values for CYP2F2 metabolism are average ± S.D. of triplicate incubations. Activities with recombinant CYP2F2 were obtained using incubation conditions unoptimized for time, reductase/P-450 ratio, or stimulation by cytochrome b5.
↵2-a Activity for recombinant human CYP1A1 (Buters et al., 1995).
↵2-b Activity for recombinant rabbit CYP2B4 (Szklarz et al., 1996).
↵2-c Activity for recombinant rabbit CYP2B5 (Szklarz et al., 1996).
↵2-d Activity for recombinant human CYP2E1 (−)-cytochromeb5 (Chen et al., 1996).
↵2-e Activity for recombinant rat CYP2E1 (−)-cytochromeb5 (Chen et al., 1996).