Table 2

Pharmacokinetic parameters for MDMA and MDA

		C_max	T_max	AUC_0–24	AUC_total^1-a	k_a^1-b	k_e	T_1/2a^1-c	T_1/2
		ng/ml	h	ng/ml · h⁻¹	ng/ml · h⁻¹	h⁻¹	h⁻¹	h	h
MDMA (125 mg)
n = 8^1-d	Mean	236.4	2.4	2623.7	3190.7	2.1253	0.0923	0.41	8.73
	±S.D.	57.97	0.98	572.90	953.24	1.1001	0.0428	0.22	3.29
n = 7^1-d	Mean	245.7	2.2	2745.5	3389.6	2.3136	0.0793	0.35	9.44
	±S.D.	55.75	0.81	494.31	831.10	1.0396	0.0238	0.13	2.83
n = 1^1-d		171.1	4	1770.7	1789.1	0.8066	0.1832	0.86	3.78
MDMA (75 mg)
n = 8	Mean	130.9	1.8	1331.5	1541.6	2.3835	0.1171	0.42	7.86
	±S.D.	38.60	0.38	646.03	721.56	2.1362	0.0818	0.20	3.58
n = 7	mean	141.6	1.7	1484.5	1720.8	2.5734	0.0910	0.39	8.66
	±S.D.	25.79	0.39	518.16	554.79	2.2332	0.0380	0.18	3.01
n = 1		55.9	2	260.7	287.4	1.0542	0.2999	0.66	2.31
MDA (125 mg)
n = 8	mean	13.7	7.1	215.2		0.7715	0.0434	1.42	27.66
	±S.D.	1.56	2.80	68.46		0.8195	0.0264	0.73	25.98
n = 7	mean	14.2	7.3	235.5		0.7864	0.0398	1.47	30.17
	±S.D.	0.96	2.98	40.40		0.8840	0.0263	0.77	26.99
n = 1		10.5	6.0	73.3		0.6671	0.0687	1.04	10.09
MDA (75 mg)
n = 8	Mean	7.8	5.1	122.3		0.7346	0.0502	1.23	16.11
	±S.D.	2.47	2.64	66.68		0.4370	0.0168	0.63	8.33
n = 7	mean	8.4	5.4	132.0		0.6073	0.0479	1.35	16.91
	±S.D.	1.84	2.70	65.63		0.2677	0.0167	0.58	8.66
n = 1		3.4	3.0	54.3		1.6254	0.0663	0.43	10.45

k_a, absorption constant;k_e, elimination constant; T_1/2a, absorption half-life; T_1/2, elimination half-life.
↵1-a Not calculated for MDA.
↵1-b Formation constant rate of MDA.
↵1-c Formation half-life of MDA.
↵1-d n = 8, all subjects; n = 7, all subjects excluding one considered an outlier; n = 1, subject considered an outlier (see text for explanations).