Table 2

Kinetic parameters2-a associated with taurocholate accumulation in hepatocytes cultured in a sandwich configuration (n= 3)

ParametersMean ± S.E.2-b
K ma(μM)28.0  ± 3.64
V ma (nmol · min−1 · mg protein−1)1.19  ± 0.07
K e4(min−1)0.849  ± 0.074
K mb(nmol · mg protein−1)1.03  ± 0.35
V mb (nmol · min−1 · mg protein−1)1.82  ± 0.36

  • ↵2-a Parameters were obtained by fitting model 13 to the average data in Fig. 6 with nonlinear least-squares regression analysis (WinNonlin).

  • ↵2-b S.E. were obtained from the WinNonlin output.