Drug | Artery + Treatment | pA2 + S.E.M. | Schild Slope | KA orKB |
---|---|---|---|---|
μM | ||||
Cys(Acm)2,7-h-αCGRP | Large coronary | 0.82 | ||
h-αCGRP(8–37) | Large coronary | −5.33 ± 0.11 | 2.44 (1.70–3.18) | 4.63 |
h-αCGRP(8–37) | Large coronary + capsaicin | −6.01 ± 0.121-b | 1.34 (1.00–1.62)1-a 1-b | 0.97 |
h-αCGRP(8–37) | Small coronary + capsaicin | −5.89 ± 0.061-b | 1.62 (1.34–1.56)1-b | 1.28 |
h-αCGRP(8–37) | Basilar | −5.85 ± 0.12 | 1.78 (1.30–2.25) | 1.44 |
h-αCGRP(8–37) | Basilar + capsaicin | −5.77 ± 0.091-c | 1.75 (1.46–2.04)1-c | 1.70 |
Each value represents data generated from three to five individual arteries, each from different animals. 95% C.I. = 95% confidence intervals are shown in parentheses.
↵1-a Not significantly different from unity (P > .05).
↵1-b Significantly different from large coronary artery without capsaicin by analysis of covariance (P < .05).
↵1-c Not significantly different from basilar artery without capsaicin by analysis of covariance (P > .05).